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Table of Contents > Drug > Diphenhydramine and Phenylephrine Print

Diphenhydramine and Phenylephrine

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Notes
Related terms
Uses
Dosing
Safety
Author information

Notes

    Related terms
    • U.S. Brand Names: Aldex® CT;Benadryl-D® Allergy & Sinus [OTC];Benadryl-D® Children's Allergy & Sinus [OTC];Dimetapp® Children's Nighttime Cold & Congestion [OTC];Robitussin® Night Time Cough & Cold [OTC];Triaminic® Children's Night Time Cold & Cough [OTC];Triaminic® Children's Thin Strips® Night Time Cold & Cough [OTC]
    • Pharmacologic Category: Alpha/Beta Agonist;Decongestant;Ethanolamine Derivative;Histamine H1 Antagonist;Histamine H1 Antagonist, First Generation

    Uses
    • It is used to ease allergy signs.
    • It is used to treat nose stuffiness.
    • Diphenhydramine blocks the allergic reaction by lowering or stopping the body's reaction to the allergen.
    • Phenylephrine shrinks swollen nose tissue and opens up passages.

    Dosing

    How to take

    • Take with or without food. Take with food if it causes an upset stomach.
    • Chewable tablet: Chew or crush well. Mix crushed tablet with food. Do not swallow whole.
    • There is a liquid (suspension, syrup) if you cannot swallow pills. Shake suspension well before use.
    • Those who have feeding tubes can also use the liquid. Flush the feeding tube before and after this drug is given.
    • Drink plenty of noncaffeine-containing liquid unless told to drink less liquid by doctor.

    Missed Dose

    • Take a missed dose as soon as you think about it.
    • If it is close to time for the next dose, skip the missed dose and return to your normal time.
    • Do not take two doses or extra doses.
    • Many times this drug is taken on an as needed basis.

    Storage

    • Store at room temperature.
    • Protect from water. Do not store in a bathroom or kitchen.

    Safety



    Warnings

    • Talk with doctor before giving this drug to a child. Check all of your child's drugs, including OTC, with doctor.
    • Unsafe reactions may happen. This drug cannot be taken while you are taking certain other drugs. Check all the drugs you are taking with your doctor.

    Avoid

    • If you have an allergy to diphenhydramine, phenylephrine, or any other part of this drug.
    • Tell doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs involved.
    • If you have taken isocarboxazid, phenelzine, or tranylcypromine in the last 14 days. Monoamine oxidase inhibitors (eg, isocarboxazid, phenelzine, and tranylcypromine) must be stopped 14 days before this drug is started. Taking the two at the same time could cause risky high blood pressure.
    • If you are breast-feeding.

    Precautions

    • This drug is not for coughs due to smoking or lung disease.
    • If you are 65 or older, use this drug with care. You could have more side effects.
    • If you have asthma, talk with doctor.
    • If you have high blood sugar (diabetes), talk with doctor.
    • If you have an enlarged prostate, talk with doctor.
    • If you have glaucoma, talk with doctor.
    • If you have heart disease, talk with doctor.
    • If you have high blood pressure, talk with doctor.
    • If you have PKU, talk with doctor. Some products do contain phenylalanine.
    • If you have thyroid disease, talk with doctor.
    • Check drugs with doctor. This drug may not mix well with other drugs.
    • You may not be alert. Avoid driving, doing other tasks or activities until you see how this drug affects you.
    • Avoid alcohol (includes wine, beer, and liquor) or other drugs and natural products that slow your actions and reactions.
    • Limit caffeine (for example, tea, coffee, cola) and chocolate intake. Use with this drug may cause nervousness, shakiness, and fast heartbeat.
    • Tell doctor if you are pregnant or plan on getting pregnant.

    Side Effects

    • Feeling lightheaded, sleepy, having blurred eyesight, or a change in thinking clearly. Avoid driving, doing other tasks or actions that call for you to be alert or have clear eyesight until you see how this drug affects you.
    • Feeling dizzy. Rise slowly over a few minutes from sitting or lying position. Be careful climbing.
    • Nervous and excitable.
    • Upset stomach or throwing up. Small frequent meals, frequent mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
    • Dry mouth. Frequent mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
    • Not able to sleep.

    Monitoring

    • Change in health problem being treated. Is it better, worse, or about the same?
    • Dry mouth may cause more cavities. Take good care of your teeth. See a dentist often.

    Contact a healthcare provider

    • If you suspect an overdose, call your local poison control center or ER right away.
    • Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat.
    • Chest pain or pressure, fast heartbeat, or passing out.
    • Trouble breathing.
    • Big change in thinking clearly and with logic.
    • Very bad headache.
    • Cough that does not go away.
    • Feeling very tired or weak.
    • Any rash.
    • Health problem is not better or you are feeling worse.

    General Statements

    • If you have a very bad allergy, wear allergy ID at all times.
    • Do not share your drugs with others and do not take anyone else's drugs.
    • Keep all drugs out of the reach of children and pets.
    • Most drugs can be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada return any unused drugs back to the pharmacy. Also, visit http://www.hc-sc.gc.ca/hl-vs/iyh-vsv/med/disposal-defaire-eng.php#th for more facts about the right way to get rid of unused drugs.
    • Keep a list of all your drugs (prescription, natural products, supplements, vitamins, OTC) with you. Give this list to your doctor.
    • Call your doctor for health help about side effects. You may also call the FDA at 1-800-FDA-1088 or in Canada to Health Canada's Canada Vigilance Program at 1-866-234-2345.
    • Talk with doctor before starting any new drug, including OTC, natural products, or vitamins.

    Author information
    • Copyright © 1978-2010 Lexi-Comp Inc. All rights reserved.

    Copyright © 2011 Natural Standard (www.naturalstandard.com)


    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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