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Table of Contents > Drug > Bupropion Print



Related terms
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    Related terms
    • Brand Names: U.S.: AplenzinT;Budeprion SR®;Budeprion XL® [DSC];Buproban®;ForfivoT XL;Wellbutrin SR®;Wellbutrin XL®;Wellbutrin®;Zyban®
    • Brand Names: Canada: Ava-Bupropion SR;Bupropion SR®;Novo-Bupropion SR;PMS-Bupropion SR;ratio-Bupropion SR;Sandoz-Bupropion SR;Wellbutrin® SR;Wellbutrin® XL;Zyban®

    • It is used to treat low mood (depression).
    • It is used to help you stop smoking.
    • It is used to treat attention deficit problems with hyperactivity.
    • Bupropion raises chemicals in the brain.
    • With low mood (depression), sleep and eating habits may get better fast. Other signs may take up to 4 to 6 weeks to get better.
    • It eases the need to smoke and helps with withdrawal signs from smoking. It does not contain nicotine.
    • It has a calming effect with attention deficit problems.


    How to take

    • To gain the most benefit, do not miss doses.
    • Take with or without food. Take with food if it causes an upset stomach.
    • Long-acting products: Swallow whole. Do not chew, break, or crush.
    • You may take this drug for 1 week before you stop smoking.
    • Nicotine products and counseling may be used at the same time for best results.
    • Take tablet early in the day to stop sleep problems. Take at least 6 hours before bedtime.

    Missed Dose

    • Take a missed dose as soon as you think about it.
    • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
    • Do not take 2 doses at the same time or extra doses.
    • Do not change the dose or stop this drug. Talk with the doctor.


    • Store at room temperature.
    • Protect from light.
    • Protect from water. Do not store in a bathroom or kitchen.



    • The want to harm yourself is an unsafe sign of low mood (depression). It may last until your low mood is fully treated. If you are planning on harming yourself, call the ER (emergency department) right away.
    • When used to stop smoking this drug may cause or make diseases of the mind worse. Taking one's own life, ideas of killing yourself or murder, low mood (depression), forceful actions, hallucinations, and psychoses have happened with use. If you think you have any of these problems, call your doctor right away.
    • Chance of seizures may be higher. Talk with the doctor.
    • Sometimes drugs are not safe when you take them with certain other drugs. Taking them together can cause bad side effects. This is one of those drugs. Be sure to talk to your doctor about all the drugs you take.
    • Please read the medication guide.


    • If you have an allergy to bupropion or any other part of this drug.
    • Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
    • If you have any of these health problems: Eating problem or seizures.
    • If you have taken isocarboxazid, phenelzine, or tranylcypromine in the last 14 days. Monoamine oxidase inhibitors (eg, isocarboxazid, phenelzine, and tranylcypromine) must be stopped 14 days before this drug is started. Taking both at the same time could cause risky high blood pressure.


    • You may have some heart tests before starting this drug. Talk with your doctor.
    • If you are allergic to tartrazine, talk with your doctor. Some products have tartrazine.
    • Do not use AplenzinT, ForfivoT XL, Wellbutrin®, or Zyban® at the same time. They are the same drug.
    • If you have been taking this drug for many weeks, talk with your doctor before stopping. You may want to slowly stop this drug.
    • If you abuse beer, wine, mixed drinks, or cocaine, talk with your doctor.
    • If you have heart disease, talk with your doctor.
    • Have your blood pressure checked often if you have heart disease or are taking a product to replace nicotine.
    • If you have kidney disease, talk with your doctor.
    • If you have liver disease, talk with your doctor.
    • Check all drugs you are taking with your doctor. This drug may not mix well with some other drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Avoid beer, wine, mixed drinks, or other drugs and natural products that slow your actions.
    • Tell your doctor if you are pregnant or plan on getting pregnant.
    • Tell your doctor if you are breast-feeding.

    Side Effects

    • Feeling lightheaded, sleepy, having blurred eyesight, or a change in thinking clearly. Avoid driving and doing other tasks or actions that call for you to be alert or have clear eyesight until you see how this drug affects you.
    • Long-acting tablet shell in the stool.
    • Hot flashes. Wearing layers of clothes or summer clothes and staying in cool places may help.
    • Headache.
    • Belly pain.
    • Shakiness.
    • Nervous and excitable.
    • Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
    • Hard stools (constipation). Drinking more liquids, working out, or adding fiber to your diet may help. Talk with your doctor about a stool softener or laxative.
    • Dry mouth. Good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help. See a dentist often.
    • Not able to sleep.
    • Bad taste in your mouth. This most often goes back to normal.
    • Not hungry.
    • Unsafe allergic effects may rarely happen.

    Contact a healthcare provider

    • If you think there was an overdose, call your local poison control center or ER right away.
    • Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat.
    • Signs of low mood (depression), thoughts of killing yourself, nervousness, emotional ups and downs, thinking that is not normal, anxiety, or lack of interest in life.
    • Change in thinking clearly and with logic.
    • A fast heartbeat.
    • Very bad headache.
    • Very nervous and excitable.
    • If you have not been able to quit smoking after taking this drug for 12 weeks.
    • If seizures are new or worse after starting this drug.
    • Any rash.
    • Side effect or health problem is not better or you are feeling worse.

    General Statements

    • If you have a very bad allergy, wear an allergy ID at all times.
    • Do not share your drugs with others and do not take anyone else's drugs.
    • Keep all drugs out of the reach of children and pets.
    • Most drugs may be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada, take any unused drugs to the pharmacy. Also, visit to learn about the right way to get rid of unused drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Call your doctor for help with any side effects. If in the U.S., you may also call the FDA at 1-800-FDA-1088 or if in Canada, you may also call Health Canada's Vigilance Program at 1-866-234-2345.
    • Talk with the doctor before starting any new drug, including OTC, natural products, or vitamins.

    Author information
    • Copyright © 1978-2013 Lexi-Comp Inc. All rights reserved.

    Copyright © 2011 Natural Standard (

    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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