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Table of Contents > Drug > Estradiol and Norethindrone Print

Estradiol and Norethindrone

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Notes
Related terms
Uses
Dosing
Safety
Author information

Notes

    Related terms
    • Brand Names: U.S.: Activella®;CombiPatch®;MimveyT
    • Brand Names: Canada: Estalis-Sequi®;Estalis®
    • Pharmacologic Category: Estrogen and Progestin Combination

    Uses
    • It is used to put off soft, brittle bones (osteoporosis) in women after change of life.
    • It is used to stop or lower the signs of stopping periods (menopause).
    • It is used when the ovaries have been taken out, are not working the right way, or have stopped working.
    • It is used to treat vaginal irritation and dryness caused by change of life.
    • When the body no longer makes estrogen, this drug puts back the estrogen.
    • Norethindrone lowers endometrial cell changes and the chance of endometrial cancer.

    Dosing

    How to take

    • Oral:
    • Take this drug at the same time of day.
    • Take this drug with food.
    • This drug works best when used with calcium/vitamin D and weight-bearing workouts like walking or PT (physical therapy).
    • Follow the diet and workout plan that your doctor told you about.
    • Skin patch:
    • Put patch on clean, dry, healthy skin. Move the site with each new patch.
    • Do not place on breast.

    Missed Dose

    • Use a missed dose as soon as you think about it.
    • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
    • Do not use 2 doses or extra doses.

    Storage

    • Store at room temperature.
    • Protect from water. Do not store in a bathroom or kitchen.

    Safety



    Warnings

    • Estrogens, when used in women after stopping periods (menopause), may raise the chance of uterine cancer. Progestins may lower this chance. A warning sign for cancer of the uterus is vaginal bleeding. Report any vaginal bleeding to your doctor.
    • Do not take estrogens to stop heart disease or dementia. Using estrogens may raise your chances of having a heart attack, a stroke, breast cancer, or a blood clot.
    • Do not take estrogens if you are pregnant. If you get pregnant while taking this drug, call your doctor right away.
    • Unsafe side effects may happen. This drug cannot be taken while you are taking some other drugs. Check all the drugs you are taking with your doctor.

    Avoid

    • If you have an allergy to estradiol, norethindrone, or any other part of this drug.
    • Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
    • If you have any of these health problems: Blood clots, breast cancer, liver disease, stroke, tumor where estrogen makes it grow, or vaginal bleeding.
    • If you are pregnant or may be pregnant.

    Precautions

    • There may be a higher chance of breast cancer.
    • If you have any blood flow problems, talk with your doctor.
    • If you have high blood pressure, talk with your doctor.
    • If you have high blood sugar (diabetes), you will need to watch your blood sugar closely.
    • If you have a weak heart, talk with your doctor.
    • Have your blood pressure checked often. Talk with your doctor.
    • Have your blood work checked. Talk with your doctor.
    • Have a bone density test. Talk with your doctor.
    • Do monthly breast self-exams and have a gynecologic exam every year.
    • Have an eye exam every year.
    • Check all drugs you are taking with your doctor. This drug may not mix well with some other drugs.
    • Limit your drinking of wine, beer, or mixed drinks.
    • Use birth control that you can trust to stop pregnancy while taking this drug.
    • Tell your doctor if you are breast-feeding.

    Side Effects

    • Headache.
    • Belly pain.
    • Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
    • Enlarged breasts.
    • Change in sex ability. This most often goes back to normal.

    Contact a healthcare provider

    • If you think there was an overdose, call your local poison control center or ER right away.
    • Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat.
    • Chest pain or pressure.
    • Trouble breathing.
    • Change in strength on 1 side is greater than the other, trouble speaking or thinking, change in balance, or blurred eyesight.
    • Swelling or pain in the leg or arm.
    • Very bad headache.
    • Very upset stomach or throwing up.
    • Change in how contact lenses feel in the eyes.
    • Sudden change in eyesight, eye pain, or irritation.
    • A lump in the breast or breast soreness.
    • For women, period changes. These include lots of bleeding, spotting, or bleeding between cycles.
    • Any rash.
    • Health problem is not better or you are feeling worse.

    General Statements

    • If you have a very bad allergy, wear an allergy ID at all times.
    • Do not share your drugs with others and do not take anyone else's drugs.
    • Keep all drugs out of the reach of children and pets.
    • Most drugs may be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada, take any unused drugs to the pharmacy. Also, visit http://www.hc-sc.gc.ca/hl-vs/iyh-vsv/med/disposal-defaire-eng.php#th to learn about the right way to get rid of unused drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Call your doctor for help with any side effects. If in the U.S., you may also call the FDA at 1-800-FDA-1088 or if in Canada, you may also call Health Canada's Vigilance Program at 1-866-234-2345.
    • Talk with the doctor before starting any new drug, including OTC, natural products, or vitamins.
    • Read the package insert for more details.

    Author information
    • Copyright © 1978-2010 Lexi-Comp Inc. All rights reserved.

    Copyright © 2011 Natural Standard (www.naturalstandard.com)


    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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