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Table of Contents > Drug > Sulfasalazine Print



Related terms
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    Related terms
    • Brand Names: U.S.: Azulfidine EN-tabs®;Azulfidine®;Sulfazine;Sulfazine EC
    • Brand Names: Canada: Alti-Sulfasalazine;Salazopyrin En-Tabs®;Salazopyrin®

    • It is used to treat rheumatoid arthritis.
    • It is used to treat ulcerative colitis.
    • Sulfasalazine lowers irritation and swelling.


    How to take

    • Take as you have been told, even if you are feeling better.
    • Take with meals.
    • Take with a full glass of water.
    • Swallow enteric-coated tablet whole. Do not chew, break, or crush.
    • Drink lots of noncaffeine liquids unless told to drink less liquid by your doctor.

    Missed Dose

    • Take a missed dose as soon as you think about it.
    • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
    • Do not take 2 doses at the same time or extra doses.


    • Store at room temperature.
    • Protect from water. Do not store in a bathroom or kitchen.



    • If you have an allergy to sulfasalazine or any other part of this drug.
    • Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
    • If you have a sulfa (sulfonamide) allergy, talk with your doctor.
    • If you have any of these health problems: Bowel block, porphyria, or trouble passing urine.


    • If you have asthma, talk with your doctor.
    • Be careful if you have G6PD deficiency. Anemia may happen.
    • If you have kidney disease, talk with your doctor.
    • If you have liver disease, talk with your doctor.
    • Have your blood work checked often. Talk with your doctor.
    • If you are taking a blood thinner, have your blood work checked. Talk with your doctor.
    • Check all drugs you are taking with your doctor. This drug may not mix well with some other drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • This drug may change the color of urine, sweat, and tears to yellow or orange color.
    • This drug may stain contact lenses.
    • Protect clothing and fabrics from staining.
    • You may get sunburned more easily. Avoid sun, sunlamps, and tanning beds. Use sunscreen and wear clothing and eyewear that protects you from the sun.
    • Sperm counts and motility may be lowered. These go back to normal within 2 months after the drug is stopped.
    • Tell your doctor if you are pregnant or plan on getting pregnant.
    • Tell your doctor if you are breast-feeding.

    Side Effects

    • Headache.
    • Belly pain or heartburn.
    • Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
    • Harm to the liver may rarely happen.

    Contact a healthcare provider

    • If you think there was an overdose, call your local poison control center or ER right away.
    • Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat.
    • Feeling very tired or weak.
    • If you see tablet bits in the stool.
    • Very bad belly pain or bloody loose stools.
    • Very upset stomach or throwing up.
    • Very bad skin irritation.
    • Yellow skin or eyes.
    • Not able to eat.
    • Any rash.
    • Side effect or health problem is not better or you are feeling worse.

    General Statements

    • If you have a very bad allergy, wear an allergy ID at all times.
    • Do not share your drugs with others and do not take anyone else's drugs.
    • Keep all drugs out of the reach of children and pets.
    • Most drugs may be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada, take any unused drugs to the pharmacy. Also, visit to learn about the right way to get rid of unused drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Call your doctor for help with any side effects. If in the U.S., you may also call the FDA at 1-800-FDA-1088 or if in Canada, you may also call Health Canada's Vigilance Program at 1-866-234-2345.
    • Talk with the doctor before starting any new drug, including OTC, natural products, or vitamins.

    Author information
    • Copyright © 1978-2013 Lexi-Comp Inc. All rights reserved.

    Copyright © 2011 Natural Standard (

    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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